10 Best Bedbug Sprays 2025 in the United States

The Ortho Home Defense Max Bed Bug, Flea, and Tick Killer is a powerful option for anyone dealing with bed bugs, fleas, and ticks. One of its key strengths is its ability to kill even pyrethroid-resistant bed bugs, making it suitable for handling tough infestations. The inclusion of the Comfort Wand is a thoughtful addition, allowing users to target hard-to-reach areas like mattress seams and baseboards effectively. This feature makes the application process easier and more precise.

The product is also versatile, addressing not just bed bugs, but their eggs, fleas, and ticks as well, which could save you from needing multiple sprays for different pests. However, one potential drawback is the odor associated with the spray, which some users might find unpleasant. On the plus side, user reviews are generally favorable, with a 4.4 out of 5-star rating from over 28,000 reviews, indicating a high level of effectiveness and customer satisfaction.

In terms of safety, as with many pest control products, it’s important to use it as directed to avoid any potential health risks, especially if you have pets or children. Finally, the spray’s 1-gallon volume offers good value, especially if you’re treating multiple areas or need to reapply over time. While it is part of a larger Ortho Bed Bug Solution System, it seems quite effective on its own for most users. This makes it a solid choice for households needing a reliable solution against bed bugs, fleas, and ticks.

The Ortho Home Defense Max Bed Bug Killer spray is designed to tackle bed bugs effectively, including those resistant to common pyrethroid insecticides. It kills both the bugs and their eggs, which is important since eggs are often hardest to eliminate. One standout feature is its residual effect: it continues killing bed bugs for up to 16 weeks on hard surfaces like ceramic, providing longer-lasting protection compared to some sprays that lose effectiveness quickly.

Its application is straightforward as a spot treatment, ideal for use around bed frames, headboards, floors, and carpets where bed bugs hide. The spray is unscented, which is good if you prefer no strong chemical odors in your home. It also targets other pests such as fleas, ticks, and various household bugs, adding extra value. Safety-wise, while the product is effective, it contains chemical ingredients and should be used carefully according to instructions, especially around pets and children.

A minor drawback is that it works best on non-porous surfaces; its long-lasting effect may be less on porous materials like fabric or wood. For best results, it is recommended to use this spray along with Ortho’s bed bug traps and powder treatments for a more complete control strategy. If you want a reliable, multi-purpose bed bug spray with a strong residual action and no odor, this product is a good choice. However, it functions best as part of a combined approach rather than a one-step solution.

The Hygea Natural Lice, Mite, and Bed Bug Travel Spray is designed as a convenient, natural option for controlling bed bugs and other pests, especially while traveling. One of its biggest advantages is safety—it uses natural, non-toxic ingredients that are child- and pet-friendly, making it a good choice if you want to avoid harsh chemicals around your family or pets. It's also odorless and stain-free, which means you can confidently use it on mattresses, upholstery, clothing, and other surfaces without worrying about unpleasant smells or marks.

The spray comes in a compact 3 oz bottle that meets TSA requirements, making it very travel-friendly for use in hotels, suitcases, or backpacks. Application is simple: just a light mist on the affected areas, following the included step-by-step guide for best results.

This spray suits travelers or families looking for a safe, gentle, and convenient bed bug treatment without strong chemicals. For quick, on-the-go use with minimal risk, Hygea Natural provides a solid, user-friendly solution.